alias	title	study_type	study_abstract	study_description
74cf43e2-11b1-42af-bf79-171ad7a58105	RNA-seq analysis of Brpf1 knockout versus wild-type neurons derived from BALB/c mouse brain [49]	RNASeq	biological replicate;genetic modification design	This study investigates the transcriptional impact of targeted knockout (KO) of the Brpf1 gene in primary mouse neurons using RNA sequencing (RNA-seq).Brain tissue was dissected from four BALB/c mice. Neuronal cells were isolated and cultured in vitro for two weeks prior to RNA extraction. A targeted knockout of Brpf1 was introduced in two samples, while two samples were maintained as wild-type controls, resulting in two biological replicates per condition.Total RNA was extracted and mRNA libraries were prepared by the EMBL Genomics Core Facility. Sequencing was performed on the Illumina HiSeq 4000 platform using paired-end mode.This dataset enables comparative transcriptomic analysis between Brpf1 knockout and wild-type neurons to assess the gene's role in neuronal gene regulation.